Executive Director, Rocky Mountain Down Syndrome Association (RMDSA)

1. Syndrome For Talking Too Much
2. Syndrome Macleod
3. Syndrome Macgregor
4. Syndrome For Captives
5. Syndrome For Attention
6. Syndrome For Compulsive Eating

Doctors treat mycobacterium avium complex (MAC) disease, the most common NTM lung infection, with a combination of three antibiotics: Either azithromycin (Zithromax) and clarithromycin (Biaxin). Organisms of the Mycobacterium avium complex (MAC) are ubiquitous in the environment. 1-6 In the era prior to the availability of effective antiretroviral therapy (ART), M. Avium was the etiologic agent in 95% of people living with HIV with advanced immunosuppression who acquired disseminated MAC disease. 4,7-12 Recent studies conducted using newer bacterial typing technology.

Mac has made a career working in the non-profit sector. Having begun his career teaching at Cherry Creek High school, he then moved on to The Nature Conservancy (Colorado Field Office) where he was a Major Gift fundraiser. Responsible for raising gifts of over $50,000, his time at TNC was spent building relationships within Colorado, and also nationally. After the birth of Guion, his first son, Mac and his wife Rebecca learned that Guion had Down syndrome. Mac decided to leave TNC due to a heavy traveling schedule to concentrate on learning more about his new son and the world of Down syndrome.

Mac began volunteering for Special Olympics Colorado which eventually led to a paid position as the Director of Development for that organization. Having been a part of the RMDSA family he was aware that the organization was in the process of searching for a new Executive Director, so Mac formally joined RMDSA as the second Executive Director in February of 2009. Mac has his Bachelor of Science from Pfeiffer University in North Carolina and his Masters of Education from Vanderbilt University: Peabody College. Mac and his wife Rebecca have three children; Guion, Hoke, and Rae.

Mycobacterium avium complex is a group of mycobacteria comprising Mycobacterium intracellulare and Mycobacterium avium that are commonly grouped because they infect humans together; this group, in turn, is part of the group of nontuberculous mycobacteria. These bacteria cause disease in humans called Mycobacterium avium-intracellulare infection or Mycobacterium avium complex infection.^[2] These bacteria are common and are found in fresh and salt water, in household dust and in soil.^[3] MAC bacteria only cause infection in those who are immunocompromised or those with severe lung disease.

Description[edit]

In the Runyon classification, both bacteria are nonchromogens. They can be differentiated from M. tuberculosis and each other by commercially available DNA probes.^[4]:245

Syndrome For Talking Too Much

They are characterized as Gram-positive, nonmotile, acid-fast, short to long rods.

Syndrome Macleod

Colony characteristics

• Usually, colonies are smooth, rarely rough, and not pigmented colonies. Older colonies may become yellow.

Syndrome Macgregor

Gorogoa download for mac os. Physiology

• Growth on Löwenstein-Jensen medium and Middlebrook 7H10 agar occurs at 37°C after seven or more days.
• The complex can be (but is not often) resistant to isoniazid, ethambutol, rifampin, and streptomycin.^[5]

Differential characteristics

• M. intracellulare and M. avium form the M. avium complex (MAC).
• Remarkable ITS heterogeneity is seen within different M. intracellulare isolates.

Type strains[edit]

M. intracellulare type strains include ATCC 13950, CCUG 28005, CIP 104243, DSM 43223, JCM 6384, and NCTC 13025.^[6]

M. avium type strains include ATCC 25291, DSM 44156, and TMC 724.^[7]

Human health[edit]

MAC bacteria enter most people's body when inhaled into the lungs or swallowed, but only cause infection in those who are immunocompromised or who have severe lung disease such as those with cystic fibrosis or chronic obstructive lung disease (COPD).^[3]MAC infection can cause COPD and lymphadenitis, and can cause disseminated disease, especially in people with immunodeficiency.^[4]:245

History[edit]

In 2004, Tortoli et al. proposed the name M. chimaera for strains that a reverse hybridization–based line probe assay suggested belonged to MAIS (M. avium–M. intracellulare–M. scrofulaceum group), but were different from M. avium, M. intracellulare, or M. scrofulaceum. The new species name comes from the Chimera, a mythological being made up of parts of three different animals.^[8][9]

References[edit]

1. ^Runyon, E. 1965. Pathogenic mycobacteria. Advances in Tuberculosis Research, 14, 235-287.
2. ^'Mycobacterium Avium Complex. MAI; MAC Information'. Patient Info. 29 August 2014.
3. ^ ^ab'Mycobacterium Avium Complex infections | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program'. rarediseases.info.nih.gov. Retrieved 2020-03-29.
4. ^ ^abJones-Lopez, Edward C.; Ellner, Jerrold J. (2011). 'Chapter 35: Tuberculosis and Atypical Mycobacterial Infections'. In Guerrant, Richard L.; Walker, David H.; Weller, Peter F. (eds.). Tropical infectious diseases : principles, pathogens, & practice (3rd ed.). Edinburgh: Saunders. ISBN9780702039355.
5. ^Haworth CS, Banks J, Capstick T, Fisher AJ, Gorsuch T, Laurenson IF, Leitch A, Loebinger MR, Milburn HJ, Nightingale M, Ormerod P, Shingadia D, Smith D, Whitehead N, Wilson R, Floto RA (November 2017). 'British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)'. Thorax. 72 (Suppl 2): ii1–ii64. doi:10.1136/thoraxjnl-2017-210927. PMID29054853.
6. ^Type strain of Mycobacterium intracellulare at BacDive - the Bacterial Diversity Metadatabase
7. ^Type strain of Mycobacterium avium at BacDive - the Bacterial Diversity Metadatabase
8. ^Henry, Ronnie (March 2017). 'Etymologia: Mycobacterium chimaera'. Emerg Infect Dis. 23 (3): 499. doi:10.3201/eid2303.ET2303. PMC5382748. Citing public domain text from the CDC.
9. ^Tortoli, E; Rindi, L; Garcia, MJ; Chiaradonna, P; Dei, R; Garzelli, C; Kroppenstedt, RM; Lari, N; Mattei, R; Mariottini, A; Mazzarelli, G; Murcia, MI; Nanetti, A; Piccoli, P; Scarparo, C (July 2004). 'Proposal to elevate the genetic variant MAC-A, included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp. nov'. International Journal of Systematic and Evolutionary Microbiology. 54 (Pt 4): 1277–85. doi:10.1099/ijs.0.02777-0. PMID15280303.

Syndrome For Captives

External links[edit]

Syndrome For Attention

• Mycobacterium avium Complex at the US National Library of Medicine Medical Subject Headings (MeSH)

Syndrome For Compulsive Eating